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PMID:9770487
| Citation |
Weng, Z, Fluckiger, AC, Nisitani, S, Wahl, MI, Le, LQ, Hunter, CA, Fernal, AA, Le Beau, MM and Witte, ON (1998) A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M. Proc. Natl. Acad. Sci. U.S.A. 95:12334-9 |
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| Abstract |
Cell cycle progression is monitored by highly coordinated checkpoint machinery, which is activated to induce cell cycle arrest until defects like DNA damage are corrected. We have isolated an anti-proliferative cell cycle regulator named G2A (for G2 accumulation), which is predominantly expressed in immature T and B lymphocyte progenitors and is a member of the seven membrane-spanning G protein-coupled receptor family. G2A overexpression attenuates the transformation potential of BCR-ABL and other oncogenes, and leads to accumulation of cells at G2/M independently of p53 and c-Abl. G2A can be induced in lymphocytes and to a lesser extent in nonlymphocyte cell lines or tissues by multiple stimuli including different classes of DNA-damaging agents and serves as a response to damage and cellular stimulation which functions to slow cell cycle progression. |
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| Keywords |
3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Cell Cycle Proteins/chemistry; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; Cloning, Molecular; DNA Damage; DNA Primers; DNA Replication; G2 Phase; GTP-Binding Proteins/metabolism; Mice; Mitosis; Molecular Sequence Data; Oxidative Stress; Rats; Receptors, G-Protein-Coupled; Signal Transduction |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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