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PMID:9714600
| Citation |
Odorizzi, G, Cowles, CR and Emr, SD (1998) The AP-3 complex: a coat of many colours. Trends Cell Biol. 8:282-8 |
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| Abstract |
A new adaptor protein complex, termed AP-3, has recently been identified in mammalian cells, and genetic studies in yeast have revealed a functional role for the AP-3 complex in cargo-selective transport via a new alternative trafficking pathway from the Golgi to the vacuole/lysosome. Here, the authors review what is currently known about the AP-3 complex and discuss recent insight into its function in multicellular organisms that has come from the finding that mutations in AP-3 subunits correspond to classical mutations in Drosophila and mice. |
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| Keywords |
Adaptor Proteins, Vesicular Transport; Animals; Biological Transport/physiology; Enzyme Inhibitors/metabolism; Eukaryotic Cells/chemistry; Eukaryotic Cells/metabolism; Golgi Apparatus/chemistry; Golgi Apparatus/metabolism; Lysosomes/chemistry; Lysosomes/metabolism; Monomeric Clathrin Assembly Proteins; Nerve Tissue Proteins/physiology; Phosphoproteins/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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