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PMID:9697864
| Citation |
Waggoner, LE, Zhou, GT, Schafer, RW and Schafer, WR (1998) Control of alternative behavioral states by serotonin in Caenorhabditis elegans. Neuron 21:203-14 |
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| Abstract |
Serotonin has been implicated in the regulation of a wide range of brain functions involving alternative behavioral states, including the control of mood, aggression, sex, and sleep. Here, we report that in the nematode Caenorhabditis elegans, serotonin controls a switch between two distinct, on/off states of egg-laying behavior. Through quantitative analysis of the temporal pattern of egg-laying events, we determined that egg laying can be modeled as a novel random process, in which animals fluctuate between discrete behavioral states: an active state, during which eggs are laid in clusters, and an inactive state, during which eggs are retained. Single-cell ablation experiments indicate that two pairs of motor neurons, HSNL/HSNR and VC4/VC5, can induce the active phase by releasing serotonin. These neurons also release acetylcholine, which appears to trigger individual egg-laying events within the active phase. Genetic experiments suggest that determination of the behavioral states observed for C. elegans egg laying may be mediated through protein kinase C-dependent (PKC-dependent) modulation of voltage-gated calcium channels. |
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| Keywords |
Acetylcholine/physiology; Animals; Behavior, Animal/physiology; Caenorhabditis elegans/genetics; Caenorhabditis elegans/physiology; Female; Models, Biological; Oviposition/physiology; Serotonin/physiology; Stochastic Processes |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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