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PMID:9627357
| Citation |
Khan, A, Zong-Chao, L, Efendic, S and Landau, BR (1998) Glucose-6-phosphatase activity in the hypothalamus of the ob/ob mouse. Metab. Clin. Exp. 47:627-9 |
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| Abstract |
The hypothalamus and cortex from ob/ob mice and their lean littermates were sonicated and then incubated with glucose-6-phosphate (glucose-6-P) and glycerol phosphate (glycerol-P). The difference between the rates of hydrolysis of glucose-6-P and glycerol-P was taken as the measure of glucose-6-phosphatase activity. The activity was much higher in the hypothalamus from ob/ob mice versus their lean littermates. Activity was undetected in the cortex. These findings raise the possibility that a defect in the regulation of glucose-6-phosphatase activity in a portion of the hypothalamus may relate to the mechanism underlying obesity in the ob/ob mouse. However, obese gene product administration to ob/ob mice, while reducing the body weight, did not alter the glucose-6-phosphatase activity. |
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| Keywords |
Animals; Glucose-6-Phosphatase/metabolism; Glucose-6-Phosphate/metabolism; Glycerophosphates/metabolism; Hydrolysis; Hypothalamus/enzymology; Mice; Mice, Mutant Strains/genetics; Obesity/enzymology; Obesity/genetics; Reference Values |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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