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PMID:9604928
| Citation |
Conradt, B and Horvitz, HR (1998) The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. Cell 93:519-29 |
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| Abstract |
Gain-of-function mutations in the Caenorhabditis elegans gene egl-1 cause the HSN neurons to undergo programmed cell death. By contrast, a loss-of-function egl-1 mutation prevents most if not all somatic programmed cell deaths. The egl-1 gene negatively regulates the ced-9 gene, which protects against cell death and is a member of the bcl-2 family. The EGL-1 protein contains a nine amino acid region similar to the Bcl-2 homology region 3 (BH3) domain but does not contain a BH1, BH2, or BH4 domain, suggesting that EGL-1 may be a member of a family of cell death activators that includes the mammalian proteins Bik, Bid, Harakiri, and Bad. The EGL-1 and CED-9 proteins interact physically. We propose that EGL-1 activates programmed cell death by binding to and directly inhibiting the activity of CED-9, perhaps by releasing the cell death activator CED-4 from a CED-9/CED-4-containing protein complex. |
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| Keywords |
Amino Acid Sequence; Animals; Apoptosis/physiology; Apoptosis Regulatory Proteins; Base Sequence; Caenorhabditis elegans/cytology; Caenorhabditis elegans/embryology; Caenorhabditis elegans/genetics; Caenorhabditis elegans Proteins; Calcium-Binding Proteins/genetics; Calcium-Binding Proteins/physiology; Caspases; Cloning, Molecular; Cysteine Endopeptidases/genetics; Cysteine Endopeptidases/physiology; Disorders of Sex Development/genetics; Gene Expression Regulation, Developmental/physiology; Genes, Helminth/genetics; Helminth Proteins/genetics; Helminth Proteins/metabolism; Helminth Proteins/physiology; Molecular Sequence Data; Neurons/cytology; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-bcl-2/genetics; Recombinant Fusion Proteins; Repressor Proteins/genetics; Repressor Proteins/metabolism; Repressor Proteins/physiology; Restriction Mapping; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Suppression, Genetic |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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