PMID:9389650

Citation	Hubbard, EJ, Wu, G, Kitajewski, J and Greenwald, I (1997) sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins. Genes Dev. 11:3182-93
Abstract	Mutations that influence lin-12 activity in Caenorhabditis elegans may identify conserved factors that regulate the activity of lin-12/Notch proteins. We describe genetic evidence indicating that sel-10 is a negative regulator of lin-12/Notch-mediated signaling in C. elegans. Sequence analysis shows that SEL-10 is a member of the CDC4 family of proteins and has a potential human ortholog. Coimmunoprecipitation data indicate that C. elegans SEL-10 complexes with LIN-12 and with murine Notch4. We propose that SEL-10 promotes the ubiquitin-mediated turnover of LIN-12/Notch proteins, and discuss potential roles for the regulation of lin-12/Notch activity by sel-10 in cell fate decisions and tumorigenesis.
Links	PubMed PMC316751
Keywords	Amino Acid Sequence; Animals; Base Sequence; Caenorhabditis elegans/genetics; Caenorhabditis elegans/metabolism; Caenorhabditis elegans Proteins; Cell Cycle Proteins/chemistry; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; Cell Differentiation/physiology; Cell Transformation, Neoplastic; Cloning, Molecular; DNA, Complementary; F-Box Proteins; Gene Dosage; Genes, Helminth; Helminth Proteins/chemistry; Helminth Proteins/genetics; Helminth Proteins/metabolism; Humans; Membrane Proteins/genetics; Membrane Proteins/metabolism; Mice; Molecular Sequence Data; Mutation; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; Receptors, Cell Surface; Receptors, Notch; Sequence Homology, Amino Acid; Signal Transduction; Ubiquitin-Protein Ligases; Ubiquitins/metabolism
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