PMID:9160749

Citation	Clark, SE, Williams, RW and Meyerowitz, EM (1997) The CLAVATA1 gene encodes a putative receptor kinase that controls shoot and floral meristem size in Arabidopsis. Cell 89:575-85
Abstract	The shoot apical meristem is responsible for above-ground organ initiation in higher plants, accomplishing continuous organogenesis by maintaining a pool of undifferentiated cells and directing descendant cells toward organ formation. Normally, proliferation and differentiation are balanced, so that the structure and size of the shoot meristem is maintained. However, Arabidopsis plants homozygous for mutations at the CLAVATA1 (CLV1) locus accumulate excess undifferentiated cells. We describe the molecular cloning and expression pattern of the CLV1 gene. It encodes a putative receptor kinase, suggesting a role in signal transduction. The extracellular domain is composed of 21 tandem leucine-rich repeats that resemble leucine-rich repeats found in animal hormone receptors. We provide evidence that CLV1 expression in the inflorescence is specifically associated with meristematic activity.
Links	PubMed
Keywords	Amino Acid Sequence; Animals; Arabidopsis/enzymology; Arabidopsis/genetics; Arabidopsis/growth & development; Base Sequence; Cloning, Molecular; DNA, Plant/genetics; Gene Expression; Genes, Plant; In Situ Hybridization; Molecular Sequence Data; Phylogeny; Plant Proteins/genetics; Plant Proteins/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; RNA, Plant/genetics; RNA, Plant/metabolism; Receptor Protein-Tyrosine Kinases/genetics; Receptor Protein-Tyrosine Kinases/metabolism; Sequence Homology, Amino Acid; Signal Transduction
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