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PMID:9084181
| Citation |
Lysenko, E, Ogura, T and Cutting, SM (1997) Characterization of the ftsH gene of Bacillus subtilis. Microbiology (Reading, Engl.) 143 ( Pt 3):971-8 |
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| Abstract |
Members of the AAA-protein family are found in both prokaryotes and eukaryotes. These ATPases are involved in a number of diverse activities ranging from protein secretion to cell cycle control. This paper reports the functional analysis of the Bacillus subtilis ftsH gene, which encodes a member of this protein family. In cells containing reduced levels of a truncated FtsH protein cell growth was impaired under certain nutritional conditions. In a hypersaline environment FtsH was required in increased amounts for the cells' recovery from osmotic stress. In the absence of FtsH the abundance of several of the major penicillin-binding proteins (PBP2A and 2B) in the cytoplasmic membrane was affected. Lastly, it has been established that FtsH is required for entry into the developmental life cycle. |
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| Keywords |
Bacillus subtilis/genetics; Bacterial Proteins/genetics; Gene Expression Regulation, Bacterial; Genes, Bacterial; Membrane Proteins/genetics; Mutation |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0006970: response to osmotic stress |
ECO:0000315: |
P |
Figure 4: Growth of the ftsH mutant was limited when the bacteria grew in medium that contained 7% NaCl. Wild type cultures experienced a lag followed by a resumption of normal growth. |
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References
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