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PMID:8955293
| Citation |
Agostini, HJ, Carroll, JD and Minton, KW (1996) Identification and characterization of uvrA, a DNA repair gene of Deinococcus radiodurans. J. Bacteriol. 178:6759-65 |
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| Abstract |
Deinococcus radiodurans is extraordinarily resistant to DNA damage, because of its unusually efficient DNA repair processes. The mtcA+ and mtcB+ genes of D. radiodurans, both implicated in excision repair, have been cloned and sequenced, showing that they are a single gene, highly homologous to the uvrA+ genes of other bacteria. The Escherichia coli uvrA+ gene was expressed in mtcA and mtcB strains, and it produced a high degree of complementation of the repair defect in these strains, suggesting that the UvrA protein of D. radiodurans is necessary but not sufficient to produce extreme DNA damage resistance. Upstream of the uvrA+ gene are two large open reading frames, both of which are directionally divergent from the uvrA+ gene. Evidence is presented that the proximal of these open reading frames may be irrB+. |
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| Keywords |
Adenosine Triphosphatases/chemistry; Adenosine Triphosphatases/genetics; Amino Acid Sequence; Bacterial Proteins/chemistry; Bacterial Proteins/genetics; Base Sequence; DNA Repair/genetics; DNA-Binding Proteins/chemistry; DNA-Binding Proteins/genetics; Escherichia coli/genetics; Escherichia coli Proteins; Genes, Bacterial; Genetic Vectors; Gram-Positive Cocci/genetics; Gram-Positive Cocci/physiology; Immunoblotting; Micrococcus/genetics; Micrococcus/physiology; Molecular Sequence Data; Open Reading Frames; Sequence Alignment; Transformation, Bacterial |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
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See also
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