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Wood, SA, Ammann, RR, Brock, DA, Li, L, Spann, T and Gomer, RH (1996) RtoA links initial cell type choice to the cell cycle in Dictyostelium. Development 122:3677-85


In Dictyostelium, initial cell type choice is correlated with the cell-cycle phase of the cell at the time of starvation. We have isolated a mutant, ratioA (rtoA), with a defect in this mechanism that results in an abnormally high percentage of prestalk cells. The rtoA gene has been cloned and sequenced and codes for a novel protein. The cell cycle is normal in rtoA. In the wild type, prestalk cells differentiate from those cells in S or early G2 phase at starvation and prespore cells from cells in late G2 or M phase at starvation. In rtoA mutants, both prestalk and prespore cells originate randomly from cells in any phase of the cell cycle at starvation.




Amino Acid Sequence; Animals; Base Sequence; Cell Cycle; Cell Cycle Proteins/genetics; Cell Differentiation; Cloning, Molecular; Dictyostelium/cytology; Dictyostelium/genetics; Genes, Fungal; Molecular Sequence Data; Morphogenesis; Mutagenesis, Insertional; Protozoan Proteins; RNA, Messenger/genetics; Video Recording



Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status

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