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PMID:8951083
| Citation |
Wood, SA, Ammann, RR, Brock, DA, Li, L, Spann, T and Gomer, RH (1996) RtoA links initial cell type choice to the cell cycle in Dictyostelium. Development 122:3677-85 |
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| Abstract |
In Dictyostelium, initial cell type choice is correlated with the cell-cycle phase of the cell at the time of starvation. We have isolated a mutant, ratioA (rtoA), with a defect in this mechanism that results in an abnormally high percentage of prestalk cells. The rtoA gene has been cloned and sequenced and codes for a novel protein. The cell cycle is normal in rtoA. In the wild type, prestalk cells differentiate from those cells in S or early G2 phase at starvation and prespore cells from cells in late G2 or M phase at starvation. In rtoA mutants, both prestalk and prespore cells originate randomly from cells in any phase of the cell cycle at starvation. |
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| Keywords |
Amino Acid Sequence; Animals; Base Sequence; Cell Cycle; Cell Cycle Proteins/genetics; Cell Differentiation; Cloning, Molecular; Dictyostelium/cytology; Dictyostelium/genetics; Genes, Fungal; Molecular Sequence Data; Morphogenesis; Mutagenesis, Insertional; Protozoan Proteins; RNA, Messenger/genetics; Video Recording |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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