GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:8940094
| Citation |
Vito, P, Wolozin, B, Ganjei, JK, Iwasaki, K, Lacanà, E and D'Adamio, L (1996) Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3. J. Biol. Chem. 271:31025-8 |
|---|---|
| Abstract |
ALG-3, a truncated mouse homologue of the chromosome 1 familial Alzheimer's disease gene PS2, rescues T hybridoma 3DO cells from T-cell receptor-induced apoptosis by inhibiting Fas ligand induction and Fas signaling. Here we show that ALG-3 transfected 3DO cells express a COOH-terminal PS2 polypeptide. Overexpression of PS2 in ALG-3 transfected 3DO cells reconstitutes sensitivity to receptor-induced cell death, suggesting that the artificial PS2 polypeptide functions as a dominant negative mutant of PS2. ALG-3 and antisense PS2 protect PC12 cells from glutamate-induced apoptosis but not from death induced by hydrogen peroxide or the free radical MPP+. Thus, the PS2 gene is required for some forms of cell death in diverse cell types, and its function is opposed by ALG-3. |
| Links | |
| Keywords |
Alzheimer Disease/genetics; Amino Acid Sequence; Animals; Apoptosis; Humans; Membrane Proteins/metabolism; Mice; Molecular Sequence Data; Presenilin-2; Sequence Alignment; Transfection |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
