PMID:8688077

Citation	Bennett, MJ, Marchant, A, Green, HG, May, ST, Ward, SP, Millner, PA, Walker, AR, Schulz, B and Feldmann, KA (1996) Arabidopsis AUX1 gene: a permease-like regulator of root gravitropism. Science 273:948-50
Abstract	The plant hormone auxin regulates various developmental processes including root formation, vascular development, and gravitropism. Mutations within the AUX1 gene confer an auxin-resistant root growth phenotype and abolish root gravitropic curvature. Polypeptide sequence similarity to amino acid permeases suggests that AUX1 mediates the transport of an amino acid-like signaling molecule. Indole-3-acetic acid, the major form of auxin in higher plants, is structurally similar to tryptophan and is a likely substrate for the AUX1 gene product. The cloned AUX1 gene can restore the auxin-responsiveness of transgenic aux1 roots. Spatially, AUX1 is expressed in root apical tissues that regulate root gravitropic curvature.
Links	PubMed
Keywords	2,4-Dichlorophenoxyacetic Acid/pharmacology; Amino Acid Sequence; Amino Acid Transport Systems; Amino Acids/metabolism; Arabidopsis/chemistry; Arabidopsis/genetics; Arabidopsis/growth & development; Arabidopsis/metabolism; Arabidopsis Proteins; Biological Transport; Cloning, Molecular; DNA, Bacterial/genetics; Genes, Plant; Genetic Complementation Test; Gravitropism; Indoleacetic Acids/metabolism; Indoleacetic Acids/pharmacology; Membrane Transport Proteins/chemistry; Molecular Sequence Data; Molecular Weight; Mutation; Plant Proteins/chemistry; Plant Proteins/genetics; Plant Proteins/metabolism; Plant Roots/growth & development; Plant Roots/metabolism; Sequence Alignment; Signal Transduction
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Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
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