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PMID:8662524
| Citation |
Liu, J, Schrank, B and Waterston, RH (1996) Interaction between a putative mechanosensory membrane channel and a collagen. Science 273:361-4 |
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| Abstract |
The degenerin family of proteins in Caenorhabditis elegans is homologous to subunits of the mammalian amiloride-sensitive epithelial sodium channels. Mutations in nematode degenerins cause cell death, probably because of defects in channel function. Genetic evidence was obtained that the unc-105 gene product represents a degenerin homolog affecting C. elegans muscles and that this putative channel interacts with type IV collagen in the extracellular matrix underlying the muscle cell. This interaction may serve as a mechanism of stretch-activated muscle contraction, and this system could provide a molecular model for the activation of mechanosensitive ion channels. |
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| Keywords |
Alleles; Amino Acid Sequence; Animals; Base Sequence; Caenorhabditis elegans/chemistry; Caenorhabditis elegans/genetics; Caenorhabditis elegans/metabolism; Caenorhabditis elegans Proteins; Cloning, Molecular; Collagen/metabolism; Extracellular Matrix/metabolism; Genes, Helminth; Genetic Complementation Test; Helminth Proteins/chemistry; Helminth Proteins/genetics; Helminth Proteins/metabolism; Helminth Proteins/physiology; Ion Channel Gating; Models, Biological; Molecular Sequence Data; Muscle Contraction; Muscles/physiology; Mutation; Sensation; Signal Transduction; Sodium Channels/chemistry; Sodium Channels/genetics; Sodium Channels/metabolism; Sodium Channels/physiology; Suppression, Genetic |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
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