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PMID:8658138
| Citation |
Nelson, JR, Lawrence, CW and Hinkle, DC (1996) Thymine-thymine dimer bypass by yeast DNA polymerase zeta. Science 272:1646-9 |
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| Abstract |
The REV3 and REV7 genes of the yeast Saccharomyces cerevisiae are required for DNA damage-induced mutagenesis. The Rev3 and Rev7 proteins were shown to form a complex with DNA polymerase activity. This polymerase replicated past a thymine-thymine cis-syn cyclobutane dimer, a lesion that normally severely inhibits replication, with an efficiency of approximately 10 percent. In contrast, bypass replication efficiency with yeast DNA polymerase alpha was no more than 1 percent. The Rev3-Rev7 complex is the sixth eukaryotic DNA polymerase to be described, and is therefore called DNA polymerase zeta. |
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| Keywords |
Base Sequence; DNA Primers; DNA Replication; DNA, Fungal/biosynthesis; DNA, Fungal/metabolism; DNA-Directed DNA Polymerase/antagonists & inhibitors; DNA-Directed DNA Polymerase/genetics; DNA-Directed DNA Polymerase/metabolism; Fungal Proteins/antagonists & inhibitors; Fungal Proteins/genetics; Fungal Proteins/metabolism; Glutathione Transferase/genetics; Glutathione Transferase/metabolism; Molecular Sequence Data; Pyrimidine Dimers/metabolism; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Saccharomyces cerevisiae/enzymology; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae Proteins |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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