PMID:8521491

Citation	Etemad-Moghadam, B, Guo, S and Kemphues, KJ (1995) Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos. Cell 83:743-52
Abstract	The par-3 gene is required for establishing polarity in early C. elegans embryos. Embryos from par-3 homozygous mothers show defects in segregation of cytoplasmic determinants and in positioning of the early cleavage spindles. We report here that the PAR-3 protein is asymmetrically distributed at the periphery of the zygote and asymmetrically dividing blastomeres of the germline lineage. The PAR-3 distribution is roughly the reciprocal of PAR-1, another protein required for establishing embryonic polarity in C. elegans. Analysis of the distribution of PAR-3 and PAR-1 in other par mutants reveals that par-2 activity is required for proper localization of PAR-3 and that PAR-3 is required for proper localization of PAR-1. In addition, the distribution of the PAR-3 protein correlates with differences in cleavage spindle orientation and suggests a mechanism by which PAR-3 contributes to control of cleavage pattern.
Links	PubMed
Keywords	Animals; Blastomeres/chemistry; Caenorhabditis elegans/embryology; Caenorhabditis elegans/genetics; Caenorhabditis elegans Proteins; Cell Cycle; Cell Polarity/physiology; Cloning, Molecular; Embryo, Nonmammalian/chemistry; Gene Expression Regulation, Developmental; Genes, Helminth/genetics; Helminth Proteins/analysis; Helminth Proteins/genetics; Helminth Proteins/physiology; Molecular Sequence Data; RNA/analysis; RNA, Helminth/analysis; Sequence Analysis, DNA; Zygote/chemistry
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