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PMID:8510757
| Citation |
Fenton, B and Glover, DM (1993) A conserved mitotic kinase active at late anaphase-telophase in syncytial Drosophila embryos. Nature 363:637-40 |
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| Abstract |
Mutations in the Drosophila gene polo cause abnormal mitotic and meiotic divisions. This gene encodes a 577-amino-acid protein that has an N-terminal putative kinase domain and a 300-residue C-terminal domain. In budding yeast, a homologous kinase is encoded by CDC5 (ref. 3), a gene required for nuclear division late in the mitotic cycle and during meiosis. Murine homologues have also been described. Here we show that the polo gene product immunoprecipitated from extracts of single Drosophila embryos can phosphorylate casein in vitro, and that the kinase activity peaks cyclically at late anaphase/telophase. This contrasts with the cyclical activity of cyclin B-associated p34cdc2 kinase, which is maximal upon entry into mitosis during the rapid cycles of mitosis in the syncytium. |
| Links |
PubMed Online version:10.1038/363637a0 |
| Keywords |
Anaphase; Animals; CDC2 Protein Kinase/metabolism; Caseins/metabolism; Cell Fusion; Cyclins/metabolism; Drosophila/embryology; Drosophila/enzymology; Drosophila Proteins; Larva/enzymology; Phosphorylation; Protein-Serine-Threonine Kinases/genetics; Protein-Serine-Threonine Kinases/metabolism; Telophase |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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