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PMID:8356051
| Citation |
Quinn, TP, Peters, KG, De Vries, C, Ferrara, N and Williams, LT (1993) Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc. Natl. Acad. Sci. U.S.A. 90:7533-7 |
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| Abstract |
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor, induces endothelial proliferation in vitro and vascular permeability in vivo. The human transmembrane c-fms-like tyrosine kinase Flt-1 has recently been identified as a VEGF receptor. Flt-1 kinase has seven immunoglobulin-like extracellular domains and a kinase insert sequence, features shared by two other human gene-encoded proteins, kinase insert domain-containing receptor (KDR) and FLT-4. In this study we show that the mouse homologue of KDR, Flk-1, is a second functional VEGF receptor. Flk-1 binds VEGF with high affinity, undergoes autophosphorylation, and mediates VEGF-dependent Ca2+ efflux in Xenopus oocytes injected with Flk-1 mRNA. We also demonstrate by in situ hybridization that Flk-1 protein expression in the mouse embryo is restricted to the vascular endothelium and the umbilical cord stroma. VEGF and its receptors Flk-1/KDR and Flt-1 may play a role in vascular development and regulation of vascular permeability. |
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| Keywords |
3T3 Cells; Amino Acid Sequence; Animals; Antisense Elements (Genetics); Base Sequence; Calcium/metabolism; Cell Line; Endothelial Growth Factors/metabolism; Endothelium, Vascular/enzymology; Female; Fetus; Gene Expression; In Situ Hybridization; Kinetics; Liver/enzymology; Lymphokines/metabolism; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Oocytes/drug effects; Oocytes/metabolism; Phosphorylation; Protein-Tyrosine Kinases/biosynthesis; Protein-Tyrosine Kinases/genetics; Protein-Tyrosine Kinases/metabolism; Receptors, Vascular Endothelial Growth Factor; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Xenopus |
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Significance
Annotations
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