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PMID:8325482
| Citation |
Avery, L, Bargmann, CI and Horvitz, HR (1993) The Caenorhabditis elegans unc-31 gene affects multiple nervous system-controlled functions. Genetics 134:455-64 |
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| Abstract |
We have devised a method for selecting Caenorhabditis elegans mutants that execute feeding motions in the absence of food. One mutation isolated in this way is an allele of the gene unc-31, first discovered by S. Brenner in 1974, because of its effects on locomotion. We find that strong unc-31 mutations cause defects in four functions controlled by the nervous system. Mutant worms are lethargic, feed constitutively, are defective in egg-laying and produce dauer larvae that fail to recover. We discuss two extreme models to explain this pleiotropy: either unc-31 affects one or a few neurons that coordinately control several different functions, or it affects many neurons that independently control different functions. |
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| Keywords |
Animals; Caenorhabditis elegans/genetics; Caenorhabditis elegans/physiology; Feeding Behavior/physiology; Female; Genes; Humans; Iron; Larva; Locomotion/genetics; Locomotion/physiology; Magnetics; Nervous System/physiopathology; Oviposition/genetics; Oviposition/physiology; Pharyngeal Muscles/physiopathology; Phenotype |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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