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PMID:8156602
| Citation |
Mello, CC, Draper, BW and Priess, JR (1994) The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo. Cell 77:95-106 |
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| Abstract |
The sister blastomeres ABp and ABa are equipotent at the beginning of the 4-cell stage in C. elegans embryos, but soon become committed to different fates. We show that the glp-1 gene, a homolog of the Notch gene of Drosophila, functions in two distinct cell-cell interactions that specify the ABp and ABa fates. These interactions both require maternal expression of glp-1. We show that a second maternal gene, apx-1, functions with glp-1 only in the specification of the ABp fate and that apx-1 can encode a protein homologous to the Delta protein of Drosophila. Our results suggest how interactions mediated by glp-1 and apx-1 contribute to the establishment of the dorsal-ventral axis in the early C. elegans embryo. |
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| Keywords |
Amino Acid Sequence; Animals; Base Sequence; Blastomeres/cytology; Caenorhabditis elegans/embryology; Caenorhabditis elegans/genetics; Caenorhabditis elegans Proteins; Cell Communication; Cell Differentiation; Cloning, Molecular; Embryonic Induction; Genes, Helminth; Membrane Glycoproteins/genetics; Membrane Proteins/genetics; Molecular Sequence Data; Morphogenesis; Pharynx/embryology; Sequence Alignment; Sequence Homology, Amino Acid; Sodium Channels |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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