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PMID:8146662
| Citation |
Suzuki, CK, Suda, K, Wang, N and Schatz, G (1994) Requirement for the yeast gene LON in intramitochondrial proteolysis and maintenance of respiration. Science 264:273-6 |
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| Abstract |
The role of protein degradation in mitochondrial homeostasis was explored by cloning of a gene from Saccharomyces cerevisiae that encodes a protein resembling the adenosine triphosphate (ATP)-dependent bacterial protease Lon. The predicted yeast protein has a typical mitochondrial matrix-targeting sequence at its amino terminus. Yeast cells lacking a functional LON gene contained a nonfunctional mitochondrial genome, were respiratory-deficient, and lacked an ATP-dependent proteolytic activity present in the mitochondria of Lon+ cells. Lon- cells were also impaired in their ability to catalyze the energy-dependent degradation of several mitochondrial matrix proteins and they accumulated electron-dense inclusions in their mitochondrial matrix. |
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| Keywords |
ATP-Dependent Proteases; Adenosine Triphosphatases/genetics; Adenosine Triphosphatases/metabolism; Amino Acid Sequence; Base Sequence; Cloning, Molecular; Fungal Proteins/metabolism; Genes, Fungal; Heat-Shock Proteins/genetics; Heat-Shock Proteins/metabolism; Microscopy, Electron; Mitochondria/metabolism; Mitochondria/ultrastructure; Molecular Sequence Data; Oxygen Consumption; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism; Serine Endopeptidases/genetics; Serine Endopeptidases/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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