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PMID:8044838
| Citation |
Penton, A, Chen, Y, Staehling-Hampton, K, Wrana, JL, Attisano, L, Szidonya, J, Cassill, JA, Massagué, J and Hoffmann, FM (1994) Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor. Cell 78:239-50 |
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| Abstract |
Drosophila sequences at chromosomal positions 25D (Brk25D) and 43E (Brk43E) are similar to the TGF beta type I receptor serine/threonine kinases and are expressed broadly during embryogenesis. Brk25D binds dpp protein and bone morphogenetic protein 2 with high affinity. Mutations affecting Brk25D map to the gene thick veins and block the expression of two decapentaplegic-responsive (dpp-responsive) genes, dpp and labial, in the embryonic midgut. Defects in Brk25D receptor function combined with reduced expression of dpp ligand produce mutant phenotypes in the embryo and adult. Brk43E is the product of the gene saxophone, which also interacts with dpp. We conclude that dpp signaling in vivo is mediated by at least two receptors, Brk25D and Brk43E. |
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| Keywords |
Amino Acid Sequence; Animals; Base Sequence; Bone Morphogenetic Proteins; Cloning, Molecular; DNA, Complementary; Drosophila/embryology; Drosophila/genetics; Drosophila Proteins; Gene Expression Regulation/physiology; Genes, Insect/genetics; Insect Hormones/genetics; Insect Hormones/metabolism; Molecular Sequence Data; Mutation/physiology; Protein-Serine-Threonine Kinases/chemistry; Protein-Serine-Threonine Kinases/genetics; Protein-Serine-Threonine Kinases/metabolism; Proteins/metabolism; RNA, Messenger/analysis; Receptors, Cell Surface/chemistry; Receptors, Cell Surface/genetics; Receptors, Cell Surface/metabolism; Receptors, Transforming Growth Factor beta/chemistry; Receptors, Transforming Growth Factor beta/genetics; Receptors, Transforming Growth Factor beta/metabolism; Sequence Alignment; Sequence Analysis, DNA; Signal Transduction/genetics; Transforming Growth Factor beta |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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