PMID:8044837

Citation	Nellen, D, Affolter, M and Basler, K (1994) Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic. Cell 78:225-37
Abstract	Members of the TGF beta superfamily of secreted signaling molecules regulate growth and cellular patterning during development and interact with specific type I and type II membrane receptors possessing a cytoplasmic serine/threonine kinase domain. We describe two members of the type I receptor family in Drosophila and demonstrate that they are encoded by the genes saxophone (sax) and thick veins (tkv). Further, we show that mutations that abolish sax or tkv activity cause phenotypes similar to partial or complete loss of activity, respectively, of the TGF beta homolog decapentaplegic (dpp). We propose that specification of distinct cell fates in response to different concentrations of dpp may be achieved combinatorially by the sax and tkv receptors.
Links	PubMed
Keywords	Amino Acid Sequence; Animals; Base Sequence; Chromosome Mapping; Cloning, Molecular; Crosses, Genetic; DNA, Complementary; Drosophila/embryology; Drosophila/genetics; Drosophila Proteins; Female; Genes, Insect/genetics; Insect Hormones/genetics; Insect Hormones/physiology; Male; Models, Biological; Molecular Sequence Data; Morphogenesis; Mutation/physiology; Phenotype; Protein-Serine-Threonine Kinases/genetics; Protein-Serine-Threonine Kinases/physiology; Receptors, Cell Surface/genetics; Receptors, Cell Surface/physiology; Receptors, Transforming Growth Factor beta/genetics; Receptors, Transforming Growth Factor beta/physiology; Sequence Analysis, DNA; Signal Transduction/genetics
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