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PMID:7969128
| Citation |
Longhese, MP, Plevani, P and Lucchini, G (1994) Replication factor A is required in vivo for DNA replication, repair, and recombination. Mol. Cell. Biol. 14:7884-90 |
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| Abstract |
Replication factor A (RF-A) is a heterotrimeric single-stranded-DNA-binding protein which is conserved in all eukaryotes. Since the availability of conditional mutants is an essential step to define functions and interactions of RF-A in vivo, we have produced and characterized mutations in the RFA1 gene, encoding the p70 subunit of the complex in Saccharomyces cerevisiae. This analysis provides the first in vivo evidence that RF-A function is critical not only for DNA replication but also for efficient DNA repair and recombination. Moreover, genetic evidence indicate that p70 interacts both with the DNA polymerase alpha-primase complex and with DNA polymerase delta. |
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| Keywords |
DNA Mutational Analysis; DNA Polymerase II/metabolism; DNA Polymerase III; DNA Primase; DNA Repair; DNA Replication; DNA, Fungal/genetics; DNA-Binding Proteins/genetics; DNA-Directed DNA Polymerase/metabolism; Fungal Proteins/genetics; RNA Nucleotidyltransferases/metabolism; Recombination, Genetic; Replication Protein A; Saccharomyces cerevisiae/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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