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PMID:7867956
| Citation |
Arthur, M, Depardieu, F, Molinas, C, Reynolds, P and Courvalin, P (1995) The vanZ gene of Tn1546 from Enterococcus faecium BM4147 confers resistance to teicoplanin. Gene 154:87-92 |
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| Abstract |
A five-gene cluster from Tn1546 confers resistance to the glycopeptide antibiotics vancomycin (Vm) and teicoplanin (Te) by synthesis of pentadepsipeptide peptidoglycan precursors terminating in D-lactate, which replaces D-alanine in the same position of precursors utilized by susceptible enterococci. Cloning and nucleotide sequencing indicated that Tn1546 contains an additional gene, designated vanZ, which confers low-level Te resistance, in the absence of the genes required for pentadepsipeptide synthesis. Analysis of cytoplasmic peptidoglycan precursors, accumulated in the presence of ramoplanin, showed that VanZ-mediated Te resistance does not involve incorporation of a substituent of D-alanine into the precursors. |
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| Keywords |
Amino Acid Sequence; Bacterial Proteins/genetics; Bacterial Proteins/physiology; Base Sequence; Cell Wall/metabolism; Cloning, Molecular; DNA Transposable Elements/genetics; Drug Resistance, Microbial/genetics; Enterococcus faecium/drug effects; Enterococcus faecium/genetics; Genes, Bacterial; Lactates/metabolism; Lactic Acid; Molecular Sequence Data; Operon; Peptidoglycan/biosynthesis; Teicoplanin/pharmacology; Vancomycin/pharmacology |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0046677: response to antibiotic |
ECO:0000314: |
P |
Table 2 shows that cells with plasmids containing the vanZ gene have a higher minimum inhibitory concentration of teicoplanin than cells without the vanZ gene. |
complete | ||||
| GO:0046677: response to antibiotic |
ECO:0000314: |
P |
Table 2 shows that cells transformed with plasmids containing vanY have higher minimum inhibitory concentrations (MIC) of vancomycin than cells without vanY. |
complete | ||||
See also
References
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