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Verschueren, K, Dewulf, N, Goumans, MJ, Lonnoy, O, Feijen, A, Grimsby, S, Vandi Spiegle, K, ten Dijke, P, Morén, A, Vanscheeuwijck, P, Heldin, CH, Miyazono, K, Mummery, C, Van Den Eijnden-Van Raaij, J and Huylebroeck, D (1995) Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogenesis. Mech. Dev. 52:109-23
Activins exert their effects by inducing heteromeric complexes of either of two different type I receptors, ActR-I or ActR-IB, and either of two type II receptors, ActR-II or ActR-IIB. We describe the cDNA cloning of the mouse homologue of human ActR-IB and analyze binding of radio-iodinated activin on type I/type II combinations of mouse receptors expressed from cDNA. We studied the distribution of ActR-I and ActR-IB mRNAs in postimplantation mouse embryos by in situ hybridization. In the 12.5-day postcoitum embryo, both mRNAs are found in the brain, spinal cord, some ganglia, vibrissae, lungs, body wall, stomach, gonads, ribs, limbs and shoulders. ActR-I mRNA, but not ActR-IB, is expressed in blood vessels, the heart, tongue, intervertebral discs and diaphragm. Conversely, only ActR-IB mRNA is detected in the olfactory region, eye, tooth primordium, esophagus, mesonephros, dorsal root ganglia and is strongly expressed in the spinal cord. Our results demonstrate similarities, but also differences and complementarities (mesenchymal versus epithelial expression) between the expression patterns of these type I receptors. Moreover, their expression patterns overlap with at least one of the type II activin receptors and/or one of activin subunits in some regions of the embryo, such as the brain, spinal cord, pituitary, whisker follicles, and the inner nuclear neuroblastic layer of the eye.
Activin Receptors; Activins; Amino Acid Sequence; Animals; Cloning, Molecular; Embryonic and Fetal Development; Female; Fetus/metabolism; Gene Expression Regulation, Developmental; Inhibins/metabolism; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Molecular Sequence Data; Morphogenesis; Organ Specificity; Pregnancy; RNA, Messenger/analysis; Receptors, Growth Factor/biosynthesis; Receptors, Growth Factor/genetics
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