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PMID:7553862
| Citation |
McMahon, HT, Missler, M, Li, C and Südhof, TC (1995) Complexins: cytosolic proteins that regulate SNAP receptor function. Cell 83:111-9 |
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| Abstract |
A family of proteins called complexins was discovered that compete with alpha-SNAP, but not synaptotagmin, for SNAP receptor binding. Complexins I and II are highly homologous hydrophilic proteins that are tightly conserved, with 100% identity among mouse, rat, and human complexin II. They are enriched in neurons where they colocalize with syntaxin and SNAP-25; in addition, complexin II is expressed ubiquitously at low levels. Complexins bind weakly to syntaxin alone and not at all to synaptobrevin and SNAP-25, but strongly to the SNAP receptor-core complex composed of these three molecules. They compete with alpha-SNAP for binding to the core complex but not with other interacting molecules, including synaptotagmin I, suggesting that the complexins regulate the sequential interactions of alpha-SNAP and synaptotagmins with the SNAP receptor during exocytosis. |
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| Keywords |
Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Brain Chemistry; Calcium/metabolism; Calcium-Binding Proteins; Carrier Proteins/metabolism; Cytosol/chemistry; Exocytosis; Gene Expression; Hippocampus/cytology; Humans; Macromolecular Substances; Membrane Fusion/physiology; Membrane Glycoproteins/metabolism; Membrane Proteins/metabolism; Membrane Proteins/physiology; Mice; Molecular Sequence Data; Nerve Tissue Proteins/chemistry; Nerve Tissue Proteins/isolation & purification; Nerve Tissue Proteins/metabolism; Nerve Tissue Proteins/physiology; Neurons/chemistry; R-SNARE Proteins; Rats; Recombinant Fusion Proteins/metabolism; SNARE Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins; Species Specificity; Synaptic Vesicles/metabolism; Synaptosomal-Associated Protein 25; Synaptotagmin I; Synaptotagmins; Vesicular Transport Proteins |
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Significance
Annotations
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