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PMID:7044293

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Citation

Harder, KJ, Nikaido, H and Matsuhashi, M (1981) Mutants of Escherichia coli that are resistant to certain beta-lactam compounds lack the ompF porin. Antimicrob. Agents Chemother. 20:549-52

Abstract

Carbenicillin-resistant mutants of Escherichia coli K-12 and B/r were found to produce greatly diminished levels of the porin coded by the ompF gene. Physiological and ecological implications of these findings are discussed.

Links

PubMed PMC181743

Keywords

Anti-Bacterial Agents/pharmacology; Bacterial Outer Membrane Proteins; Carbenicillin/pharmacology; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli/metabolism; Genes, Bacterial; Membrane Proteins/biosynthesis; Mutation; Penicillin Resistance

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

ECOLI:OMPF

involved_in

GO:0006855: drug transmembrane transport

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ECOLI:OMPF

enables

GO:0015238: drug transmembrane transporter activity

ECO:0000315: mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete


See also

References

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