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PMID:7033565
| Citation |
McCorquodale, DJ, Chen, CW, Joseph, MK and Woychik, R (1981) Modification of RNA polymerase from Escherichia coli by pre-early gene products of bacteriophage T5. J. Virol. 40:958-62 |
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| Abstract |
RNA polymerase from cells of Escherichia coli infected with T5 were recovered as a complex with two pre-early phage-coded polypeptides, the 60,000-dalton product of gene A1 and a previously reported 11,000-dalton polypeptide. This RNA polymerase complex had altered transcriptional specificity, in that it transcribed pre-early genes less efficiently than it did early genes. |
| Links | |
| Keywords |
DNA-Directed RNA Polymerases/metabolism; Escherichia coli/enzymology; Gene Expression Regulation; Genes, Viral; T-Phages/genetics; Transcription, Genetic; Viral Proteins/genetics; Viral Proteins/physiology |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0039657: suppression by virus of host gene expression |
ECO:0000315: |
P |
A mutation in A1 was found to prevent supression of pre-early gene transcription and is likely involved in the shut off of pre-early gene expression by some type of interaction with host RNA polymerase |
complete | ||||
Notes
See also
References
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