GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:6577128
| Citation |
Silver, JE and Fredrickson, TN (1983) A new gene that controls the type of leukemia induced by Friend murine leukemia virus. J. Exp. Med. 158:493-505 |
|---|---|
| Abstract |
NB tropic Friend murine leukemia virus (F-MuLV) replicates equally well in BALB/c and C57BL mice inoculated as neonates but causes almost exclusively erythroblastosis in BALB/c mice and nonerythroid (lymphoid and myelogenous) leukemias in C57BL mice. The C57BL resistance to erythroblastosis appears to be controlled by a single dominant gene in first and second backcrosses to BALB/c. This resistance to erythroblastosis is distinct from other genes known to affect susceptibility to Friend virus including Fv-1, Fv-2, H-2, Rfv-3, Fv-4, and Rmcf. We suggest the name Fhe for the new gene controlling susceptibility to Friend helper virus erythroblastosis. |
| Links | |
| Keywords |
Animals; Crosses, Genetic; Erythroblasts/pathology; Erythrocytes/pathology; Friend murine leukemia virus/growth & development; Genes, Dominant; Immunity, Innate; Leukemia, Experimental/etiology; Leukemia, Experimental/genetics; Leukemia, Experimental/pathology; Leukemia, Myeloid, Acute/etiology; Leukemia, Myeloid, Acute/genetics; Lymphoma/etiology; Lymphoma/genetics; Mice; Mice, Inbred BALB C/genetics; Mice, Inbred C57BL/genetics |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
See also
References
See Help:References for how to manage references in GONUTS.
