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PMID:4903176

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Citation

Eggen, K and Nathans, D (1969) Regulation of protein synthesis directed by coliphage MS2 RNA. II. In vitro repression by phage coat protein. J. Mol. Biol. 39:293-305

Abstract

No abstract in PubMed

Links

PubMed

Keywords

Autoradiography; Binding Sites; Carbon Isotopes; Cell-Free System; Coliphages; Densitometry; Enzyme Repression; Escherichia coli; Histidine/metabolism; Kinetics; Ligases/metabolism; RNA, Messenger/metabolism; Ribonucleases; Threonine/metabolism; Viral Proteins/biosynthesis; Viral Proteins/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

BPMS2:COAT

GO:1904972: negative regulation of viral translation

ECO:0000314:

P

Incubation of MS2 coat protein with RNA showed significantly decreased phage protein production through 14C-labeled proteins and radioautography. The coat protein was shown to have specific inhibitory effect on its homologous RNA, and formed a complex when bound to the RNA. Fig. 5 shows that formation of this complex strongly correlates to inhibitory effect.

complete
CACAO 11874

Notes

See also

References

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