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PMID:4031470
| Citation |
Ahmed, F and Shire, JG Lysosomal mutations inhibit lipofuscinosis of the spleen in C57BL mice. J. Hered. 76:311-2 |
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| Abstract |
Beige, bg, and reduced pigmentation, rp, are recessive mutations affecting lysosomal function. Homozygosity for beige prevented lipofuscinosis of the spleen in C57BL mice and its incidence was greatly reduced by homozygosity for rp. Dilute (d) homozygotes, with normal lysosomes, were susceptible to lipofuscinosis even though their melanosomes were more severely affected than those of beige mice. |
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| Keywords |
Animals; Crosses, Genetic; Genotype; Heterozygote; Homozygote; Lipofuscin/genetics; Lysosomes/metabolism; Mice; Mice, Inbred C57BL; Mutation; Pigments, Biological/genetics; Spleen/metabolism; Splenic Diseases/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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