GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:3783318
| Citation |
Messer, A and Flaherty, L (1986) Autosomal dominance in a late-onset motor neuron disease in the mouse. J. Neurogenet. 3:345-55 |
|---|---|
| Abstract |
A late-onset neurological disease has been identified in a substrain of C57Bl/6 mice. The disorder is characterized by hindlimb weakness and ataxia starting at 5-11 months of age, progressing to severe spastic paralysis of all limbs, with premature death. Histopathology reveals degeneration of upper and lower motoneurons. Both sexes are affected; the mice are fertile, although breeding efficiency is reduced. In outcrosses to wild-type, symptoms have been observed in all obligate heterozygotes, with a similar age range for onset to that of homozygotes. We have designated this autosomal dominant disorder Motor neuron degeneration (Mnd). |
| Links | |
| Keywords |
Animals; Behavior, Animal/physiology; Disease Models, Animal; Female; Genes, Dominant; Male; Mice; Mice, Inbred C57BL; Motor Neurons/pathology; Nerve Degeneration; Neuromuscular Diseases/genetics; Neuromuscular Diseases/pathology; Neuromuscular Diseases/physiopathology; Reproduction |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
