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PMID:3413199
| Citation |
Shimosato, K (1988) Urinary excretion of p-hydroxylated methamphetamine metabolites in man. II. Effect of alcohol intake on methamphetamine metabolism. Pharmacol. Biochem. Behav. 29:733-40 |
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| Abstract |
The effect of drinking alcoholic beverages on methamphetamine metabolism was investigated in man. The subjects, 97 males and 9 females, were divided into three groups by evaluation of their urinary pH; i.e., acidic, subacidic and neutral groups. The subjects in each group were further divided into ethanol-positive subjects and ethanol-negative subjects, depending on the presence or absence of ethanol in their urine. Gas chromatographic analysis showed the urinary concentrations of methamphetamine in the ethanol-positive subjects to be higher than those in the ethanol-negative subjects in both the acidic and subacidic urinary pH groups. Liquid chromatography, on the other hand, showed the urinary concentrations of p-hydroxymethamphetamine and p-hydroxyamphetamine for the ethanol-positive subjects to be lower than those for the ethanol-negative subjects in all three groups. The relative proportions of p-hydroxylated metabolites to unchanged methamphetamine in urine, therefore, were severely reduced in the ethanol-positive subjects. These results suggest that drinking alcoholic beverages probably results in a suppression of methamphetamine metabolism in man. |
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| Keywords |
Adult; Amphetamine/metabolism; Amphetamine/urine; Ethanol/pharmacology; Female; Humans; Hydrogen-Ion Concentration; Male; Methamphetamine/analogs & derivatives; Methamphetamine/metabolism; Methamphetamine/urine; p-Hydroxyamphetamine/urine |
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