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PMID:3079672

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Citation

Henikoff, S, Keene, MA, Fechtel, K and Fristrom, JW (1986) Gene within a gene: nested Drosophila genes encode unrelated proteins on opposite DNA strands. Cell 44:33-42

Abstract

A pupal cuticle protein gene has been found within an intron of a Drosophila gene that encodes three purine pathway enzymatic activities. The intronic gene is encoded on the DNA strand opposite the purine pathway gene and is itself interrupted by an intron. Whereas the purine pathway gene is active throughout development, the intronic cuticle protein gene is expressed primarily over a 3 hr period in the abdominal epidermal cells of prepupae that secrete the pupal cuticle. Therefore, a housekeeping gene and a developmentally regulated gene function in a nested arrangement.

Links

PubMed

Keywords

Acyltransferases/genetics; Animals; Base Sequence; Carbon-Nitrogen Ligases; DNA/genetics; Drosophila melanogaster/genetics; Drosophila melanogaster/growth & development; Drosophila melanogaster/metabolism; Gene Expression Regulation; Genes; Genetic Code; Hydroxymethyl and Formyl Transferases; Insect Hormones/genetics; Insect Proteins; Larva; Ligases/genetics; Phosphoribosylglycinamide Formyltransferase; Pupa; RNA Processing, Post-Transcriptional; RNA, Messenger/genetics; RNA, Messenger/metabolism

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


See also

References

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