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PMID:30305030
| Citation |
Luo, P, Yun, L, Li, Y, Tian, Y, Liu, Q, Huang, W and Hu, C (2018) Complete genomic sequence of the Vibrio alginolyticus bacteriophage Vp670 and characterization of the lysis-related genes, cwlQ and holA. BMC Genomics 19:741 |
|---|---|
| Abstract |
Biocontrol of bacterial pathogens by bacteriophages (phages) represents a promising strategy. Vibrio alginolyticus, a gram-negative bacterium, is a notorious pathogen responsible for the loss of economically important farmed marine animals. To date, few V. alginolyticus phages have been successfully isolated, and only three complete genome sequences of them have been released. The limited available phage resources and poor genomic data hamper research on V. alginolyticus phages and their applications for the biocontrol of V. alginolyticus. |
| Links |
PubMed PMC6180450 Online version:10.1186/s12864-018-5131-x |
| Keywords |
Bacteriophages/genetics; Bacteriophages/physiology; Genes, Viral/genetics; Genomics; Phylogeny; Vibrio alginolyticus/virology; Virus Replication/genetics |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0016787: hydrolase activity |
ECO:0000255: match to sequence model evidence used in manual assertion |
F |
CwlQ (orf8) shows strong identity to other known hydrolases. UniProtKB: A0A1L7DQ03 (A0A1L7DQ03_9CAUD) Organism: Vibrio phage Vp670 UniProt submitted name: Endolysin |
Missing: with/from | ||||
| GO:0019835: cytolysis |
ECO:0001165: colony counting evidence used in manual assertion |
P |
Fig. 6 shows that recombinantly expressed HolA reduced the survival rate of both E. coli and V. alginolyticus. UniProtKB: A0A1L7DPV8 (A0A1L7DPV8_9CAUD) Organism: Vibrio phage Vp670 UniProt submitted name: Holin |
complete | ||||
| GO:0033644: host cell membrane |
ECO:0005649: machine learning prediction of motif instance evidence used in manual assertion |
C |
Fig. 5 shows prediction of transmembrane domain at C-terminus by TMHMM and shows a hydrophilic C-terminus by a hydrophilicity analysis. UniProtKB: A0A1L7DPV8 (A0A1L7DPV8_9CAUD) Organism: Vibrio phage Vp670 UniProt submitted name: Holin |
complete | ||||
Notes
See also
References
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