PMID:28041793

Citation	Reiten, I, Uslu, FE, Fore, S, Pelgrims, R, Ringers, C, Diaz Verdugo, C, Hoffman, M, Lal, P, Kawakami, K, Pekkan, K, Yaksi, E and Jurisch-Yaksi, N (2017) Motile-Cilia-Mediated Flow Improves Sensitivity and Temporal Resolution of Olfactory Computations. Curr. Biol. 27:166-174
Abstract	Motile cilia are actively beating hair-like structures that cover the surface of multiple epithelia. The flow that ciliary beating generates is utilized for diverse functions and depends on the spatial location and biophysical properties of cilia. Here we show that the motile cilia in the nose of aquatic vertebrates are spatially organized and stably beat with an asymmetric pattern, resulting in a robust and stereotypical flow around the nose. Our results demonstrate that these flow fields attract odors to the nose pit and facilitate detection of odors by the olfactory system in stagnant environments. Moreover, we show that ciliary beating quickly exchanges the content of the nose, thereby improving the temporal resolution of the olfactory system for detecting dynamic changes of odor plumes in turbulent environments. Altogether, our work unravels a central function of ciliary beating for generating flow fields that increase the sensitivity and the temporal resolution of olfactory computations in the vertebrate brain.
Links	PubMed Online version:10.1016/j.cub.2016.11.036
Keywords	Animals; Biophysical Phenomena; Cilia/physiology; Epithelium/physiology; Nose/physiology; Odorants; Olfactory Receptor Neurons/cytology; Olfactory Receptor Neurons/metabolism; Signal Transduction; Smell; Zebrafish/physiology; Zebrafish Proteins/metabolism
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
DANRE:CC103	involved_in	GO:0003351: epithelial cilium movement	ECO:0000315: mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-786	P		Seeded From UniProt	complete

References

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