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PMID:27439604
| Citation |
Cao, Z, Dou, C, Li, J, Tang, X, Xiang, J, Zhao, C, Zhu, L, Bai, Y, Xiang, Q and Dong, S (2016) Cordycepin inhibits chondrocyte hypertrophy of mesenchymal stem cells through PI3K/Bapx1 and Notch signaling pathway. BMB Rep 49:548-553 |
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| Abstract |
Mesenchymal stem cells (MSCs) are widely used in cartilage tissue engineering to repair articular cartilage defects. However, hypertrophy of chondrocytes derived from MSCs might hinder the stabilization of hyaline cartilage. Thus, it is very important to find a suitable way to maintain the chondrogenic phenotype of chondrocytes. It has been reported that cordycepin has anti-inflammatory and anti-tumor functions. However, the role of cordycepin in chondrocyte hypertrophy remains unclear. Therefore, the objective of this study was to determine the effect of cordycepin on chondrogenesis and chondrocyte hypertrophy in MSCs and ATDC5 cells. Cordycepin upregulated chondrogenic markers including Sox9 and collagen type II while down-regulated hypertrophic markers including Runx2 and collagen type X. Further exploration showed that cordycepin promoted chondrogenesis through inhibiting Nrf2 while activating BMP signaling. Besides, cordycepin suppressed chondrocyte hypertrophy through PI3K/Bapx1 pathway and Notch signaling. Our results indicated cordycepin had the potential to maintain chondrocyte phenotype and reconstruct engineered cartilage. [BMB Reports 2016; 49(10): 548-553]. |
| Links | |
| Keywords |
Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Cell Differentiation/drug effects; Cells, Cultured; Chondrocytes/cytology; Chondrocytes/drug effects; Chondrocytes/metabolism; Chondrogenesis/drug effects; Collagen Type II/metabolism; Collagen Type X/metabolism; Core Binding Factor Alpha 1 Subunit/genetics; Core Binding Factor Alpha 1 Subunit/metabolism; Deoxyadenosines/chemistry; Deoxyadenosines/pharmacology; Down-Regulation/drug effects; Homeodomain Proteins/metabolism; Humans; Mesenchymal Stromal Cells/cytology; Mesenchymal Stromal Cells/drug effects; Mesenchymal Stromal Cells/metabolism; NF-E2-Related Factor 2/genetics; NF-E2-Related Factor 2/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Real-Time Polymerase Chain Reaction; Receptors, Notch/genetics; Receptors, Notch/metabolism; SOX9 Transcription Factor/genetics; SOX9 Transcription Factor/metabolism; Signal Transduction/drug effects; Transcription Factors/metabolism; Up-Regulation/drug effects |
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