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PMID:2708325
| Citation |
Ubukata, K, Nonoguchi, R, Matsuhashi, M and Konno, M (1989) Expression and inducibility in Staphylococcus aureus of the mecA gene, which encodes a methicillin-resistant S. aureus-specific penicillin-binding protein. J. Bacteriol. 171:2882-5 |
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| Abstract |
A beta-lactam-sensitive strain of Staphylococcus aureus could be converted to methicillin resistance by the introduction of a plasmid carrying the 4.3-kilobase HindIII chromosomal DNA fragment which encoded the mecA gene from a methicillin-resistant S. aureus. Transformant cells produced methicillin-resistant S. aureus-specific penicillin-binding protein constitutively, and additional insertion of an inducible penicillinase plasmid caused production of the pencillin-binding protein to become inducible. |
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| Keywords |
Bacterial Proteins; Carrier Proteins/genetics; Cloning, Molecular; Gene Expression Regulation; Hexosyltransferases; Muramoylpentapeptide Carboxypeptidase/genetics; Penicillin Resistance; Penicillin-Binding Proteins; Peptidyl Transferases; Staphylococcus aureus/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0046677: response to antibiotic |
ECO:0000314: |
P |
Fig. 2 shows the production of penicillin binding protein (PBP) in strains of Staphylococcus aureus transformed with pSP53 with the mecA gene. |
complete | ||||
See also
References
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