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PMID:26743457
| Citation |
'Fernandes da Costa, SP, Mot, D, Geeraerts, S, Bokori-Brown, M, Immerseel, FV and Titball, RW (2016) Variable protection against experimental broiler necrotic enteritis after immunisation with the C-terminal fragment of Clostridium perfringens alpha-toxin and a non-toxic NetB variant. Avian Pathol. ':1-26 |
|---|---|
| Abstract |
Necrotic enteritis toxin B (NetB) is a pore-forming toxin produced by Clostridium perfringens and has been shown to play a key role in avian necrotic enteritis (NE), a disease causing significant costs to the poultry production industry worldwide. The aim of this work was to determine whether immunisation with a non-toxic variant of NetB (NetB W262A) and the C-terminal fragment of C. perfringens alpha-toxin (CPA247-370) would provide protection against experimental NE. Immunised animals with either antigen or a combination of antigens developed serum antibody levels against NetB and CPA. When CPA247-370 and NetB W262A were used in combination as immunogens, an increased protection was observed after oral challenge by individual dosing, but not after in-feed challenge. |
| Links |
PubMed Online version:10.1080/03079457.2015.1129663 |
| Keywords |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0009405: pathogenesis |
ECO:0000314: |
P |
Necrotic enteritis was challenged in birds after immunization with genetic toxoids. Antibody response of various treatment groups of birds was tested using ELISA after immunization. |
complete | ||||
Notes
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References
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