PMID:25890299

Citation	Zhang, R, Thamm, DH and Misra, V (2015) The effect of Zhangfei/CREBZF on cell growth, differentiation, apoptosis, migration, and the unfolded protein response in several canine osteosarcoma cell lines. BMC Vet. Res. 11:22
Abstract	We had previously shown that the bLZip domain-containing transcription factor, Zhangfei/CREBZF inhibits the growth and the unfolded protein response (UPR) in cells of the D-17 canine osteosarcoma (OS) line and that the effects of Zhangfei are mediated by it stabilizing the tumour suppressor protein p53. To determine if our observations with D-17 cells applied more universally to canine OS, we examined three other independently isolated canine OS cell lines--Abrams, McKinley and Gracie.
Links	PubMed PMC4326286 Online version:10.1186/s12917-015-0331-y
Keywords	Animals; Apoptosis/physiology; Basic-Leucine Zipper Transcription Factors/physiology; Bone Neoplasms/physiopathology; Cell Differentiation/physiology; Cell Line, Tumor; Cell Movement/physiology; Dog Diseases/physiopathology; Dogs; Osteosarcoma/physiopathology; Real-Time Polymerase Chain Reaction; Tumor Suppressor Protein p53/physiology; Unfolded Protein Response/physiology
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
CANLF:A0A0C5E1H5		GO:1900119: positive regulation of execution phase of apoptosis	ECO:0000314:		P		Fig. 3- Zhangfei causes canine osteosarcoma cells to commit apoptosis.	complete CACAO 13352
CANLF:P53		GO:0045944: positive regulation of transcription by RNA polymerase II	ECO:0000314:		P		Figure 1 shows that cellular tumor antigen p53 (referred to as tumor suppressor protein p53 or just p53 in the paper) used in the experiment is functional within the canine (Canis lupus familiaris or Canis familiaris) osteosarcoma cells. There is a positive regulation of transcription by RNA polymerase II.	complete CACAO 13444

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