PMID:2587025

Citation	Hansen, LL, Wiek, J, Schade, M, Müller-Stolzenburg, N and Wiederholt, M (1989) Effect and compatibility of isovolaemic haemodilution in the treatment of ischaemic and non-ischaemic central retinal vein occlusion. Ophthalmologica 199:90-9
Abstract	In a prospective study, 48 eyes with non-ischaemic and 35 with ischaemic central retinal vein occlusion (CRVO) were treated by isovolaemic haemodilution (IHD). Two or more cardiovascular risk factors were present in 42% of patients with non-ischaemic and in 69% of patients with ischaemic CRVO (p less than 0.025). Nevertheless, IHD in no case caused serious cardiovascular complications. Minor problems were short fainting spells in 5% and a general weakness in 16% of the haemodiluted patients. The effect of IHD was measured by determining the time of maximal venous filling (tmvf) in fluorescein angiographies. Lowering the packed cell volume to 32-35% accelerated the tmvf from 18.4 +/- 1.61 to 13.1 +/- 1.0 s (p less than 0.001) in eyes with non-ischaemic CRVO and from 24.5 +/- 1.2 to 14.8 +/- 1.3 s (p less than 0.001) in eyes with ischaemic CRVO. After 3 months, an increase in visual acuity had occurred in 27% of eyes with non-ischaemic CRVO and in 48.5% with ischaemic CRVO. These improvement rates could nearly be maintained after 1 year. 59% of eyes with non-ischaemic and 25% with ischaemic CRVO were able to read (visual acuity greater than or equal to 6/15) after 1 year.
Links	PubMed Online version:10.1159/000310023
Keywords	Cardiovascular Diseases/complications; Fluorescein Angiography; Follow-Up Studies; Hematocrit; Hemodilution; Humans; Ischemia/therapy; Light Coagulation; Prospective Studies; Retinal Vein Occlusion/blood; Retinal Vein Occlusion/complications; Retinal Vein Occlusion/therapy; Risk Factors; Visual Acuity
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