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PMID:25777009
| Citation |
Song, C, Sundqvist, G, Malm, E, de Bruijn, I, Kumar, A, van de Mortel, J, Bulone, V and Raaijmakers, JM (2015) Lipopeptide biosynthesis in Pseudomonas fluorescens is regulated by the protease complex ClpAP. BMC Microbiol. 15:367 |
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| Abstract |
Lipopeptides (LP) are structurally diverse compounds with potent surfactant and broad-spectrum antibiotic activities. In Pseudomonas and other bacterial genera, LP biosynthesis is governed by large multimodular nonribosomal peptide synthetases (NRPS). To date, relatively little is known about the regulatory genetic network of LP biosynthesis. |
| Links |
PubMed PMC4332742 Online version:10.1186/s12866-015-0367-y |
| Keywords |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
Contributes to |
GO:0042158: lipoprotein biosynthetic process |
ECO:0000315: |
P |
Fig. 2B shows that mutants lacking clpA do not produce massetolide A (lipopeptide) and that complementation of clpA restores production of the lipoprotein. This indicates that ClpA is required for lipopeptide biosynethesis. |
complete | |||
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Contributes to |
GO:0071978: bacterial-type flagellum-dependent swarming motility |
ECO:0000315: |
P |
Fig. 2C Shows that clpA mutants are unable to swarm, a process dependent on massetolide A. This is restored with a complement. |
complete | |||
Notes
See also
References
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