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PMID:25644304
| Citation |
Kikuchi, H, Nakayama, M, Kawai, C, Kuribayashi, F, Mimuro, H, Imajoh-Ohmi, S, Nishitoh, H, Takami, Y and Nakayama, T' (2015) The histone acetyltransferase p300/CBP-associated factor acts as an effective suppressor of secretory immunoglobulin synthesis in immature B cells. Microbiol. Immunol. ' |
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| Abstract |
The histone acetyltransferase p300/CBP-associated factor (PCAF) catalyzes the acetylation of core histones, and plays important roles in epigenetics via altering the chromatin structure in vertebrates. Here, by analyzing the PCAF-deficient DT40 mutants, we report that PCAF participates in regulation of secretory IgM heavy chain (H-chain) synthesis. PCAF-deficiency remarkably caused an increase in the level of secretory IgM H-chain mRNA, but not those of IgM light chain and membrane-bound IgM H-chain mRNAs, resulting in dramatic up-regulation of the amount of secretory IgM protein. These results suggest that PCAF regulates soluble antibody production as an effective suppressor of secretory IgM H-chain synthesis. |
| Links |
PubMed Online version:10.1111/1348-0421.12237 |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004402: histone acetyltransferase activity |
ECO:0000314: |
F |
This paper provides necessary information about the function and use of histone acetyltransferase 300 that is useful for the making of this annotation. |
complete | ||||
Notes
See also
References
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