PMID:25497093

Citation	Brust, RD, Corcoran, AE, Richerson, GB, Nattie, E and Dymecki, SM (2014) Functional and developmental identification of a molecular subtype of brain serotonergic neuron specialized to regulate breathing dynamics. Cell Rep 9:2152-65
Abstract	Serotonergic neurons modulate behavioral and physiological responses from aggression and anxiety to breathing and thermoregulation. Disorders involving serotonin (5HT) dysregulation are commensurately heterogeneous and numerous. We hypothesized that this breadth in functionality derives in part from a developmentally determined substructure of distinct subtypes of 5HT neurons each specialized to modulate specific behaviors. By manipulating developmentally defined subgroups one by one chemogenetically, we find that the Egr2-Pet1 subgroup is specialized to drive increased ventilation in response to carbon dioxide elevation and acidosis. Furthermore, this subtype exhibits intrinsic chemosensitivity and modality-specific projections-increasing firing during hypercapnic acidosis and selectively projecting to respiratory chemosensory but not motor centers, respectively. These findings show that serotonergic regulation of the respiratory chemoreflex is mediated by a specialized molecular subtype of 5HT neuron harboring unique physiological, biophysical, and hodological properties specified developmentally and demonstrate that the serotonergic system contains specialized modules contributing to its collective functional breadth.
Links	PubMed PMC4351711 Online version:10.1016/j.celrep.2014.11.027
Keywords
edit table

Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
MOUSE:D3Z4G7		GO:0071310: cellular response to organic substance	ECO:0000315:		P		Figure 3 Egr2-Pet1 5HT Neurons Specialize in Regulating Breathing in Response to Tissue CO2 Elevation and Acidosis in Mice.	complete CACAO 10879

References

See Help:References for how to manage references in GONUTS.