PMID:25156738

Citation	Rumbo, C, Tomás, M, Fernández Moreira, E, Soares, NC, Carvajal, M, Santillana, E, Beceiro, A, Romero, A and Bou, G' (2014) The Acinetobacter baumannii Omp33-36 porin is a virulence factor that induces apoptosis and modulates autophagy in human cells. Infect. Immun. '
Abstract	Acinetobacter baumannii is an extracellular opportunistic human pathogen that is becoming increasingly problematic in hospitals. In the present study, we demonstrated that the A. baumannii Omp33-36 KDa protein (Omp33-36) is a porin that acts as a channel for the passage of water. The protein is found on the cell surface and is released along with other porins in the outer membrane vesicles (OMVs). In immune and connective cell tissue, this protein induced apoptosis by activation of caspases and modulation of autophagy with the consequent accumulation of p62/SQSTM1 (sequestosome 1) and LC3B-II (confirmed by use of autophagy inhibitors). Blockage of autophagy enables the bacterium to persist intracellularly (inside autophagosomes) with the subsequent development of cytotoxicity. Finally, we used animal models to confirm that Omp33-36 is a virulence factor in A. baumannii. Overall, the study findings show that Omp33-36 plays an important role in the pathogenesis of A. baumannii infections.
Links	PubMed Online version:10.1128/IAI.02034-14
Keywords
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
ACIBA:Q5K1Z4		GO:0052150: positive regulation by symbiont of host apoptotic process	ECO:0000314:		P		Figure 2b-d	complete CACAO 10152
ACIBA:Q5K1Z4	involved_in	GO:0052150: modulation by symbiont of host apoptotic process	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete

References

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