PMID:24698180

Citation	'Shao, Y and Bassler, BL (2014) Quorum regulatory small RNAs repress type VI secretion in Vibrio cholerae. Mol. Microbiol. '
Abstract	Type VI secretion is critical for Vibrio cholerae to successfully combat phagocytic eukaryotes and to survive in the presence of competing bacterial species. V. cholerae type VI secretion system genes are encoded in one large and two small clusters. In V. cholerae, type VI secretion is controlled by quorum sensing, the cell-cell communication process that enables bacteria to orchestrate group behaviors. The quorum-sensing response regulator LuxO represses type VI secretion genes at low cell density and the quorum-sensing regulator HapR activates type VI secretion genes at high cell density. We demonstrate that the quorum-regulatory small RNAs (Qrr sRNAs) that function between LuxO and HapR in the quorum-sensing cascade are required for these regulatory effects. The Qrr sRNAs control type VI secretion via two mechanisms: they repress expression of the large type VI secretion system cluster through base pairing and they repress HapR, the activator of the two small type VI secretion clusters. This regulatory arrangement ensures that the large cluster encoding many components of the secretory machine is expressed prior to the two small clusters that encode the secreted effectors. Qrr sRNA-dependent regulation of the type VI secretion system is conserved in pandemic and non-pandemic V. cholerae strains.
Links	PubMed Online version:10.1111/mmi.12599
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
VIBHA:LUXO		GO:0008218: bioluminescence	ECO:0000315:		P		Figure 2 shows the LuxO is a bioluminescence repressor, by looking at a mutant that always has LuxO activated, and therefore bioluminescence does not occur.	complete CACAO 9969

References

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