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PMID:24670089
| Citation |
Martínez-Granero, F, Redondo-Nieto, M, Vesga, P, Martín, M and Rivilla, R (2014) AmrZ is a global transcriptional regulator implicated in iron uptake and environmental adaption in P. fluorescens F113. BMC Genomics 15:237 |
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| Abstract |
AmrZ, a RHH transcriptional regulator, regulates motility and alginate production in pseudomonads. Expression of amrZ depends on the environmental stress sigma factor AlgU. amrZ and algU mutants have been shown to be impaired in environmental fitness in different pseudomonads with different lifestyles. Considering the importance of AmrZ for the ecological fitness of pseudomonads and taking advantage of the full sequencing and annotation of the Pseudomonas fluorescens F113 genome, we have carried out a ChIP-seq analysis from a pool of eight independent ChIP assays in order to determine the AmrZ binding sites and its implication in the regulation of genes involved in environmental adaption. |
| Links |
PubMed Online version:10.1186/1471-2164-15-237 |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0045892: negative regulation of transcription, DNA-templated |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0045892: negative regulation of transcription, DNA-templated |
ECO:0000315: |
P |
Figure 4 shows the expression levels of 10 genes involved in iron homeostasis in both the wild type samples and amrZ mutants. In both of the iron sufficient and iron deficient mediums, the amrZ mutants displayed significantly higher levels of iron gene expression, suggesting that amrZ plays a role in suppressing these genes. |
complete | ||||
See also
References
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