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PMID:24044555
| Citation |
Schmeisser, MJ, Kühl, SJ, Schoen, M, Beth, NH, Weis, TM, Grabrucker, AM, Kühl, M and Boeckers, TM (2013) The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons. Neural Dev 8:18 |
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| Abstract |
Circuit formation in the nervous system essentially relies on the proper development of neurons and their processes. In this context, the ubiquitin ligase Nedd4 is a crucial modulator of axonal and dendritic branching. |
| Links |
PubMed Online version:10.1186/1749-8104-8-18 |
| Keywords |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0061550: cranial ganglion development |
ECO:0000315: |
P |
Figure 4D and E indicate that embryos with wild-type n4bp3 have normal cranial ganglia development, while those with a knockout mutation experience a high degree of abnormal cranial ganglion development |
complete | ||||
| GO:0048755: branching morphogenesis of a nerve |
ECO:0000315: |
P |
Figures 4D shows that embryos with a knockout mutation in n4bp3 have significantly less branching points in their cranial nerves compared to the wild type. |
complete | ||||
| GO:0061564: axon development |
ECO:0000315: |
P |
In Figure 3C and 3D, it is seen that embryos with a knockout mutation in n4bp3 show a significant lack of development in axonal branching than what is seen in the wild type |
complete | ||||
See also
References
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