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PMID:23815882
| Citation |
Randhawa, H, Chikara, S, Gehring, D, Yildirim, T, Menon, J and Reindl, KM (2013) Overexpression of peptide deformylase in breast, colon, and lung cancers. BMC Cancer 13:321 |
|---|---|
| Abstract |
Human mitochondrial peptide deformylase (PDF) has been proposed as a novel cancer therapeutic target. However, very little is known about its expression and regulation in human tissues. The purpose of this study was to characterize the expression pattern of PDF in cancerous tissues and to identify mechanisms that regulate its expression. |
| Links |
PubMed PMC3722014 Online version:10.1186/1471-2407-13-321 |
| Keywords |
Amidohydrolases/analysis; Amidohydrolases/biosynthesis; Aminopeptidases/analysis; Aminopeptidases/biosynthesis; Blotting, Western; Breast Neoplasms/metabolism; Colonic Neoplasms/metabolism; Female; Humans; Lung Neoplasms/metabolism; Male; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction/physiology; Tissue Array Analysis; Tumor Markers, Biological/analysis |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0042586: peptide deformylase activity |
ECO:0000314: |
F |
The study suggests necessary information about peptide deformylase activity |
complete | ||||
Notes
See also
References
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