PMID:23683934

Citation	Passaia, G, Spagnolo Fonini, L, Caverzan, A, Jardim-Messeder, D, Christoff, AP, Gaeta, ML, de Araujo Mariath, JE, Margis, R and Margis-Pinheiro, M (2013) The mitochondrial glutathione peroxidase GPX3 is essential for H2O2 homeostasis and root and shoot development in rice. Plant Sci. 208:93-101
Abstract	Glutathione (GSH) peroxidases (GPXs: EC 1.11.1.9 and EC1.11.1.12) are non-heme thiol peroxidases that catalyze the reduction of H2O2 or organic hydroperoxides to water, and they have been identified in almost all kingdoms of life. The rice glutathione peroxidase (OsGPX) gene family is comprised of 5 members spread throughout a range of sub cellular compartments. The OsGPX gene family is induced in response to exogenous H2O2 and cold stress. In contrast, they are down regulated in response to drought and UV-B light treatments. Transgenic rice plants have been generated that lack mitochondrial OsGPX3. These GPX3s plants showed shorter roots and shoots compared to non-transformed (NT) plants, and higher amounts of H2O2 mitochondrial release were observed in the roots of these plants cultivated under normal conditions. This accumulation of H2O2 is positively associated with shorter root length in GPX3s plants compared to NT ones. Moreover, GPX3 promoter analysis indicated that it is mainly expressed in root tissue. These results suggest that silencing the mitochondrial OsGPX3 gene impairs normal plant development and leads to a stress-induced morphogenic response via H2O2 accumulation.
Links	PubMed Online version:10.1016/j.plantsci.2013.03.017
Keywords
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
ORYSJ:Q6ESJ0		GO:2000280: regulation of root development	ECO:0000315:		P		Figure 4E shows that three GPX3 post-transcriptional knockdown transgenic lines exhibit shorter root lengths when compared to control plants normalized for GPX3 expression.	complete CACAO 8452
ORYSJ:Q6ESJ0		GO:0048831: regulation of shoot system development	ECO:0000315:		P		Figure 4D shows that three GPX3 post-transcriptional knockdown transgenic lines exhibit shorter shoot lengths when compared to control plants normalized for GPX3 expression.	complete CACAO 8453
ORYSJ:Q6ESJ0	involved_in	GO:0048831: regulation of shoot system development	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
ORYSJ:Q6ESJ0	involved_in	GO:2000280: regulation of root development	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete

References

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